Dr. Megan Wright
Assistant Professor of Biology
Dr. Wright received her B.S. in Biomedical Sciences from Drexel University (2002) and her Ph.D. in Neuroscience from Drexel University College of Medicine (2007). She completed her postdoctoral fellowship in the lab of Dr. Ahmet Hoke in the Neurology Department at Johns Hopkins School of Medicine before joining the faculty at Arcadia University in the fall of 2010.
Dr. Wright teaches in the General Biology sequence (BI-101, 102), Neurobiology (BI335), Pathophysiology (BI336), Nutrition (BI285)and Research Methods (BI-242) for the Biology Department. She also teaches Medical Physiology (GC502) for the Genetic Counseling graduate program and has co-taught Mechanisms of Disease (PA524) for the Physician Assistant program. Her previous teaching experiences include courses in Human Anatomy, Human Physiology and Medical Neuroscience.
Dr. Wright’s general research interests are related to how peripheral axons and Schwann cells (the glial cells of the peripheral nervous system) communicate following injury, during development and in association with certain disease states. Using a variety of approaches including standard biochemical and molecular assays, in vitro models of axon-Schwann cell interactions, and in vivo rodent models of axonal regeneration, Dr. Wright studies the basic biology of Schwann cells and how these cells contribute to functional recovery following injury.
*indicates Arcadia University student
- Li K, Nicaise C, Sannie D, Hala TJ, Javed E, *Parker JL, Putatunda R, Regan KA, Suain V, Brion JP, Rhoderick F, Wright MC, Poulsen DJ, Lepore AC. Overexpression of the Astrocyte Glutamate Transporter GLT1 Exacerbates Phrenic Motor Neuron Degeneration, Diaphragm Compromise, and Forelimb Motor Dysfunction following Cervical Contusion Spinal Cord Injury. Neurosci. 2014 May 28;34(22):7622-38
- C Nicaise, D Frank, T Hala, M Authelet, R Pochet, JP Brion, MC Wright and AC Lepore. Early phrenic motor neuron loss and transient respiratory abnormalities following unilateral cervical spinal cord contusion. Journal of Neurotrauma. J Neurotrauma. 2013 Jun 15;30(12):1092-9
- Nicaise C, Putatunda R, Hala TJ, Regan KA, Frank DM, Brion JP, Leroy K, Pochet R, Wright MC, Lepore AC. Degeneration of Phrenic Motor Neurons Induces Long-Term Diaphragm Deficits following Mid-Cervical Spinal Contusion in Mice. Journal of Neurotrauma. 2012 Dec 10;29(18):2748-60
- Nicaise C, Hala TJ, Frank DM, *Parker JL, Authelet M, Leroy K, Brion JP, Wright MC, Lepore AC. Phrenic motor neuron degeneration compromises phrenic axonal circuitry and diaphragm activity in a unilateral cervical contusion model of spinal cord injury. Experimental Neurology. 2012 Jun;235(2):539-52
- Wright, MC, A Kim, YJ Son. Subcutaneous administration of muscarinic antagonists and triple-immunostaining of the Levator auris longus muscle in mice. The Journal of Visual Experiments. 2011;(55). pii: 3124
- AC Lepore, C Tolmie, J O’Donnell, MC Wright, C Dejea, B Rauck, A Hoke, AR Ignagni, RP Onders and NJ Maragakis, Peripheral Hyperstimulation Alters Site of Disease Onset and Course in SOD1G93A Rats. Neurobiology of Disease. 2010 Sep;39(3):252-64.
- MC Wright, S Potluri, X Wang, E Dentcheva, D Gautam, A Tessler, J Wess, and YJ Son. Distinct muscarinic acetylcholine receptor subtypes contribute to stability and growth, but not compensatory plasticity, of neuromuscular synapses. The Journal of Neuroscience. 2009 Nov 25;29(47):14942-55.
- MC Wright, WJ Cho, YJ Son. Distinct patterns of motor nerve terminal sprouting induced by ciliary neurotrophic factor vs. botulinum toxin. Journal of Comparative Neurology. 2007; Sep 1;504(1):1-16.
- MC Wright, YJ Son. Ciliary neurotrophic factor is not required for terminal sprouting and compensatory reinnervation of neuromuscular synapses: re-evaluation of CNTF null mice. Experimental Neurology 2007;Jun;205(2):437-48.