R. Wesley Rose, III
Associate Professor of Biology
Dr. Wes Rose received his B.A. in Biology from Franklin and Marshall College (1994), his M.S. in Biomedical Chemistry from Thomas Jefferson University (1998), and his Ph.D. in Biology from the University of Pennsylvania (2003). His post-doctoral training was conducted at the Fox Chase Cancer Center in Viral Pathogenesis and Immunology.
Dr. Rose teaches Cell Biology (BI325), Immunology (BI337), Microbiology (BI323), General Biology I (BI101), and Senior Seminar in Biology (BI490).
Infections of the central nervous system (CNS) pose a particular challenge to the immune system: the CNS is “immunologcally privileged”, meaning that the CNS is not readily accessible to the immune system. But in most cases, infections of the CNS are cleared efficiently, with minimal detriment to the host organism. Dr. Rose’s research focuses on understanding how the immune system eliminates viral infections of the mammalian CNS, while sparing this essential organ system. His work utilizes in vitro techniques, including primary cell isolation, culture, and manipulation, protein biochemistry, and molecular biology techniques. In collaboration with Dr. Glenn Rall at the Fox Chase Cancer Center, Dr. Rose also utilizes transgenic mice to study immune-mediated viral clearance from the CNS in vivo.
Recent and Representative Publications
- Podolsky, M.A., Solomos, A.C., Durso, L.C., Evans, S.M., Rall, G.F., and Rose, R.W. (2012) Extended JAK activation and delayed STAT1 dephosphorylation contribute to the distinct signal transduction kinetics of CNS neurons exposed to interferon gamma. Journal of Neuroimmunology 251: 33-38.
- O’Donnell, L.A., Conway, S., Rose, R.W., Nicolas, E., Slifker, M., Balachandran, S., and Rall, G.F. (2012) STAT1 independent control of a neurotropic measles virus challenge in primary neurons and infected mice. Journal of Immunology 188(4): 1915-23.
- Rose, R.W., Vorobyeva, A.G., Skipworth, J.D., Nicolas, E., and Rall, G.F. (2007) Altered levels of STAT1 and STAT3 influence the neuronal response to interferon gamma. Journal of Neuroimmunology 192: 145-156.
- Haddad A., Rose R.W., Pohlschroder M. (2005) "The Haloferax volcanii FtsY homolog is critical for haloarchaeal growth but does not require the A domain." Journal of Bacteriology 187(12): 4015-22. Link
- Pohlschröder, M., Dilks, K.J., Hand, N.J., and Rose, R.W. (2004) "Translocation of proteins across archaeal cytoplasmic membranes." FEMS Microbiology Reviews 28(1): 3-24. Link
- Dilks, K.J., Rose, R.W., Hartmann, E., and Pohlschröder, M. (2003) "Prokaryotic utilization of the twin arginine translocation pathway: a genomic survey." Journal of Bacteriology 185(4): 1478-1483. Link
- Rose, R.W. and Pohlschröder, M. (2002) "In vivo analysis of an essential archaeal signal recognition particle in its native host." Journal of Bacteriology 184(12): 3260-3267. Link
- M.A. Podolsky, A.C. Solomos, G.F. Rall, and R.W. Rose. Extended JAK activation and delayed STAT1 dephosphorylation contribute to the altered signal transduction kinetics in CNS neurons exposed to IFNg. American Society for Cell Biology 50th Annual Meeting, Philadelphia, PA (December 2010)
- Rose, R.W., Skipworth, J.D., Nicolas, E., & Rall, G.F. (2006). "Altered kinetics of STAT activation in interferon gamma-stimulated neurons." Presented at International Society for NeuroVirology: 7th International Symposium on NeuroVirology, Philadelphia, PA (June 2006) and FASEB Summer Research Conference: “Neural-Immune Interactions: Pathological Mechanisms and Repair”, Tucson, AZ (August 2006).